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Invest Ophthalmol Vis Sci. 2000 Feb;41(2):505-12.

Erbium: YAG laser ablation of retinal tissue under perfluorodecaline: determination of laser-tissue interaction in pig eyes.

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Department of Ophthalmology, University of Freiburg, Germany.



To evaluate the effect of Er;YAG laser on pig retina using a perfluorodecaline/retina interphase with the goal of precisely determining the extent of retinal tissue ablation.


Free running (tau = 250 microsec) Er:YAG laser pulses were transmitted through a zirconium fluoride (ZrF4) fiber guarded by quartz rod (d = 1000 microm). Laser pulses were applied to the retinal surface of enucleated pig eyes. Eyes were mounted in a specially designed rotating sample holder. The fiber probe was elevated 1.0 +/- 0.3 mm above the retinal surface with perfluorodecaline serving as transmitting medium. The laser energy was applied in a circular pattern with a radius of 3.0 mm. Radiant exposures were set to 1, 3, 5, and 10 J/cm2.


Tissue ablation linearly increased with radiant exposure from 3.2 +/- 3.7 microm at 1 J/cm2 up to 40.9 +/- 12.9 microm at 10 J/cm2. Thermal tissue changes extended 70 +/- 10 microm vertically into the retina and 25 +/- 5 microm horizontally. Distortion of outer photoreceptor segments was noticed when the retina was exposed to radiant exposures of 3 J/cm2 or higher.


The Er:YAG laser in combination with perfluorodecaline produced precise ablation of the pig retina, which suggests the feasibility of this technique for safe ablation of epiretinal membranes.

[Indexed for MEDLINE]

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