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Ann Neurol. 2000 Feb;47(2):246-9.

Major depression is a risk factor for seizures in older adults.

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Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA.


We tested the hypothesis that major depression meeting DSM-III-R criteria or medical therapies for depression increase the risk for unprovoked seizures. Major depression was associated with a sixfold increased risk for unprovoked seizures (95% CI, 1.56-22). The risk remained increased even when controlling for age, sex, length of medical follow-up, and medical therapies for depression. In the absence of known prior neurological insult, major depression is associated with an increased risk for unprovoked seizures.

[Indexed for MEDLINE]

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