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Trends Microbiol. 2000 Feb;8(2):77-81.

The origin of prokaryotic C2H2 zinc finger regulators.

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Davis Crown Gall Group, University of California, One Shields Avenue, Davis, CA 95616, USA.


C2H2 zinc finger bearing proteins are a large superfamily of nucleic acid binding proteins, which constitute a major subset of eukaryotic transcription factors. Although originally thought to occur only in eukaryotes, a novel C2H2 zinc finger transcription factor, Ros, which regulates both prokaryotic and eukaryotic promoters has been found in bacteria. Phylogenically, Ros is distantly related to eukaryotic zinc finger regulators.

[Indexed for MEDLINE]

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