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Trends Biochem Sci. 2000 Feb;25(2):70-4.

Anticodon nucleases.

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Dept of Biochemistry, Tel Aviv University, Ramat Aviv 69978, Israel.


A tRNALys-specific anticodon nuclease is kept in a latent form in a rare Escherichia coli strain, complexed with a DNA restriction enzyme. A phage T4 inhibitor of DNA restriction activates anticodon nuclease, but other T4 proteins restore tRNALys. Detection of a homologous system in Neisseria and a different anticodon nuclease in colicin E5 suggest ubiquity and diversity of such tRNA toxins. Analysis of these systems could reveal novel RNA recognition and cleavage mechanisms.

[Indexed for MEDLINE]

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