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Trends Biochem Sci. 2000 Feb;25(2):64-70.

Signaling inputs converge on nuclear effectors in TGF-beta signaling.

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Ludwig Institute for Cancer Research, Box 595, S-751 24 Uppsala, Sweden.


Recent studies have consolidated the pivotal role of Smads as intracellular effectors of TGF-beta family members. Upon binding to their specific type I and type II serine/threonine kinase receptors, each family member activates a particular subset of Smad proteins. Activated, receptor-regulated Smads form hetero-oligomeric complexes with common-partner Smads that translocate into the nucleus, where they control the expression of target genes in a cell-type-specific manner. Smads appear to function not only as nuclear effectors for TGF-beta family members, but as signal integrators within an extensive intracellular network.

[Indexed for MEDLINE]

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