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Hum Immunol. 2000 Jan;61(1):1-6.

The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering.

Author information

1
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. bottino@ermes.cba.unige.it

Abstract

The cytolytic activity mediated by human natural killer (NK) cells is the result of a balance between signals delivered by inhibitory and activating receptors. The inhibitory receptors are represented by different families of HLA-specific receptors characterized by immunoreceptor tyrosine-based inhibiting motif(ITIM) sequences in their cytoplasmic portion. The function and the specificity of the inhibitory receptors imply the existence of triggering receptors specific for non-HLA ligands that are responsible for the induction of the cytolytic activity against HLA class I-deficient target cells. These receptors have remained elusive until recently when three distinct NK-specific molecules, termed natural cytotoxicity receptors (NCR), were identified and cloned. The different members of this novel family of receptors play a complementary role in the recognition and lysis of target cells. The NCR family is composed by a heterogeneous group of molecules belonging to the Ig superfamily that associate to different immunoreceptor tyrosine-based activating motif (ITAM)-containing signal transducing polypeptides.

PMID:
10658972
DOI:
10.1016/s0198-8859(99)00162-7
[Indexed for MEDLINE]

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