Format

Send to

Choose Destination
Bioorg Med Chem. 1999 Dec;7(12):2749-52.

A new convenient transformation of erythromycin A into clarithromycin.

Author information

1
Dipartimento di Chimica e Biochimica Medica, University of Milan, Italy. pietro.allevi@unimi.it

Abstract

Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4''-hydroxy groups, methylation of the resulting 2',4''-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.

PMID:
10658579
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center