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J Pediatr. 2000 Feb;136(2):248-50.

Sickle-cell disease not identified by newborn screening because of prior transfusion.

Author information

1
Children's Hospital Oakland, Department of Hematology/Oncology, Oakland, CA 94609, USA.

Abstract

Erythrocyte transfusion can impair detection of sickle-cell disease, galactosemia, or biotinidase deficiency with newborn screening. We report on 4 infants with SCD in whom delayed diagnosis was associated with neonatal transfusion. In 2 cases, the initial newborn screening showed no hemoglobin S. In no case was the recommended screening >/=120 days from the last transfusion obtained. Two children had significant SCD-related morbidity before diagnosis.

PMID:
10657834
DOI:
10.1016/s0022-3476(00)70110-7
[Indexed for MEDLINE]

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