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J Infect Dis. 2000 Feb;181 Suppl 1:S116-20.

The pathology of diphtheria.

Author information

1
Armed Forces Institute of Pathology, Washington, DC 20306, USA. hadfield@afip.osd.mil

Abstract

Diphtheria is an acute, communicable disease caused by Corynebacterium diphtheriae. The disease is generally characterized by local growth of the bacterium in the pharynx with pseudomembrane formation or, less commonly, in the stomach or lungs; systemic dissemination of toxin then invokes lesions in distant organs. Acute disease of the upper respiratory tract usually involves one or more of the following: tonsillar zones, larynx, soft palate, uvula, and nasal cavities. A recent epidemic in Russia emphasized the role of vaccination in reducing disease in children and adults.

PMID:
10657202
DOI:
10.1086/315551
[Indexed for MEDLINE]

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