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Nat Genet. 2000 Feb;24(2):103-4.

Pushing the envelope on lipodystrophy.

Abstract

Autosomal dominant partial lipodystrophy (PLD), in which regional adipose loss is coupled with insulin resistance, is strongly associated with missense mutations in LMNA, encoding lamin A/C-a component of the nuclear envelope. This finding indicates that other proteins and functions of the nuclear envelope may have bearing on disorders of adipose tissue and insulin action.

PMID:
10655047
DOI:
10.1038/72734
[Indexed for MEDLINE]

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