Format

Send to

Choose Destination
Bioessays. 2000 Feb;22(2):124-37.

Mammalian chromodomain proteins: their role in genome organisation and expression.

Author information

1
Nuclear Reprogramming Laboratory, Division of Integrative Biology, Roslin Institute (Edinburgh), Roslin, Midlothian, Scotland.

Abstract

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the regulation of gene expression and genome organisation. BioEssays 22:124-137, 2000.

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center