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Trends Genet. 2000 Feb;16(2):75-83.

Functions of LIM-homeobox genes.

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Columbia University, College of Physicians and Surgeons, Department of Biochemistry and Molecular Biophysics, 701 W.168th Street, New York, NY 10032, USA.


Homeobox genes play fundamental roles in development. They can be subdivided into several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of LIM-homeobox genes has been remarkably conserved through evolution. Have their functions similarly been conserved? A host of new data has been derived from mutational analysis in diverse organisms, such as nematodes, flies and vertebrates. These studies have revealed a prominent involvement of LIM-homeodomain proteins in tissue patterning and differentiation, and their function in neural patterning is evident in all organisms studied to date. Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements.

[Indexed for MEDLINE]

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