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Trends Genet. 2000 Feb;16(2):51-3.

RAP, RAP, open up! New wrinkles for RAP1 in yeast.

Author information

1
Molecular Genetics Program, Wadsworth Center, New York State Dept of Health, and State University of New York School of Public Health, Albany, NY 12201-2002, USA. randall.morse@wadsworth.org

Abstract

RAP1 (repressor/activator protein 1) from budding yeast is well known for its involvement in gene activation and repression, telomere structure and function, and replication. Recent studies have examined additional roles for RAP1 in heterochromatin boundary-element formation, creation of hotspots for meiotic recombination, and chromatin opening. These studies provide new insight into the ability of this abundant DNA-binding protein to participate in a diverse array of functions taking place in a chromatin environment.

PMID:
10652526
DOI:
10.1016/s0168-9525(99)01936-8
[Indexed for MEDLINE]

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