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Trends Cell Biol. 2000 Feb;10(2):54-9.

Dosage compensation: making 1X equal 2X.

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Dept of Biology, Tufts University, Medford, MA 02155, USA.


Animals that have XX females and XY or XO males have differing doses of X-linked genes in each sex. Overcoming this is the most immediate and vital aspect of sexual differentiation. A number of systems that accurately compensate for sex-chromosome dosage have evolved independently: silencing a single X chromosome in female mammals, downregulating both X chromosomes in hermaphrodite Caenorhabditis elegans and upregulating the X chromosome in male Drosophila all equalize X-linked gene expression. Each organism uses a largely non-overlapping set of molecules to achieve the same outcome: 1X = 2X.

[Indexed for MEDLINE]

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