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FEMS Microbiol Lett. 2000 Feb 1;183(1):165-9.

Streptococcus mutans strain N produces a novel low molecular mass non-lantibiotic bacteriocin.

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Department of Microbiology, University of Otago, Dunedin, New Zealand.


Streptococcus mutans strain N was shown to have bacteriocin production and immunity characteristics consistent with those of Group I mutacin-producing strains of S. mutans. The bacteriocin mutacin N was purified from agar cultures of S. mutans strain N using XAD andp6 reversed phase chromatography. The molecular mass of mutacin N was 4806 Da and the entire 49 amino acid sequence was determined by N-terminal sequencing. Database searches indicate that mutacin N is a novel bacteriocin, but with some homology to the protein IIC domain of a hypothetical sugar-phosphotransferase enzyme from Acholeplasma florum.

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