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FEBS Lett. 2000 Jan 21;466(1):6-10.

Bcl-2 family: life-or-death switch.

Author information

1
Department of Medical Genetics, Biomedical Research Center, Osaka University Graduate School of Medicine, CREST of Japan Science and Technology Corp. (JST), 2-2 Yamadaoka, Suita, Osaka, Japan. tsuijimot@gene.med.osaka-u.ac.jp

Abstract

The Bcl-2 family of proteins that consists of anti-apoptotic and pro-apoptotic members determines life-or-death of a cell by controlling the release of mitochondrial apoptogenic factors, cytochrome c and apoptosis-inducing factor (AIF), that activate downstream executional phases, including the activation of death proteases called caspases. Cytochrome c release is, thus, central to apoptotic signal transduction in mammals, making study of the mechanism for cytochrome c release a major issue. Several models for cytochrome c release have been proposed, including rupture of mitochondrial outer membrane and involvement of a specific channel. Here, we provide an overview of recent findings on the role of Bcl-2 family members in the life-or-death decision of a cell.

PMID:
10648802
DOI:
10.1016/s0014-5793(99)01761-5
[Indexed for MEDLINE]
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