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Br J Psychiatry. 1999 Sep;175:259-62.

Association of low serum total cholesterol with major depression and suicide.

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1
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland. timo.partonen@ktl.fi

Abstract

BACKGROUND:

It has been suggested that low serum total cholesterol is associated with an increased risk of suicide.

AIMS:

To study the association between serum total cholesterol, depression and suicide using versatile, prospective data.

METHOD:

A total of 29,133 men aged 50-69 years were followed up for 5-8 years. Baseline blood samples were analysed for serum total and high-density lipoprotein cholesterol concentrations. Self-reported depression was recorded, data on hospital treatments due to depressive disorders were derived from the National Hospital Discharge Register and deaths from suicide were identified from death certificates.

RESULTS:

Low serum total cholesterol was associated with low mood and subsequently a heightened risk of hospital treatment due to major depressive disorder and of death from suicide.

CONCLUSIONS:

Our results suggest that low serum total cholesterol appears to be associated with low mood and thus to predict its serious consequences.

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PMID:
10645328
[Indexed for MEDLINE]
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