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J Virol. 2000 Feb;74(4):2005-10.

Varicella-zoster virus proteins in skin lesions: implications for a novel role of ORF29p in chickenpox.

Author information

1
Departments of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA. paa5@columbia.edu

Abstract

Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.

PMID:
10644373
PMCID:
PMC111678
[Indexed for MEDLINE]
Free PMC Article
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