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Int J Obes Relat Metab Disord. 1999 Dec;23(12):1269-75.

Effects of inactivity and diet composition on human energy balance.

Author information

1
MRC Dunn Clinical Nutrition Centre, Cambridge, UK. Peter.Murgatroyd@mrc-dunn.cam.ac.uk

Abstract

OBJECTIVES:

To investigate the influences of inactivity and dietary macronutrient composition on energy and fat balance and to look for interactions between them.

DESIGN:

Two-day measurements of energy expenditure and substrate oxidation on five occasions; ad libitum food intake from diets of 35% and 60% energy as fat, with and without imposed activity, and a fixed overfeeding at 35% fat with free activity.

SUBJECTS:

Eight normal-weight male volunteers.

MEASUREMENTS:

Energy expenditure and substrate oxidation by indirect whole-body calorimetry, and macronutrient intakes from food consumption on ad libitum regimens.

RESULTS:

Subjects consumed the same energy, mean 11.6 MJ/d, regardless of activity level, on the 35% diet. Subjects consumed more energy on the 60% than the 35% diet, mean 14 vs. 11.6 MJ/d. Inactivity induced a strong positive energy balance: 5.1 (60% diet), and 2.6 MJ/d (35% diet). Energy balance with activity was not significantly different between diets, nor significantly different from zero: 1.1 MJ/d (60% diet), and -0.2 MJ/d (35% diet). When intentionally overfed, subjects failed to compensate by raising voluntary activity.

CONCLUSION:

Energy intake was not regulated over a 2-day period in response to either imposition of inactivity or a high-fat diet. Activity proved essential to the avoidance of significant positive energy balance.

PMID:
10643683
[Indexed for MEDLINE]
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