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Cell Calcium. 1999 Nov;26(5):201-8.

Calcium signal transduction from caveolae.

Author information

1
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas 75235-9039, USA.

Abstract

Caveolae are specialized membrane microdomains that are found on the plasma membrane of most cells. Recent studies indicate that a variety of signaling molecules are highly organized in caveolae, where their interactions initiate specific signaling cascades. Molecules enriched in this membrane include G protein-coupled receptors, heterotrimeric GTP binding proteins, IP3 receptor-like protein, Ca2+ ATPase, eNOS, and several PKC isoforms. Direct measurements of calcium changes in endothelial cells suggest that caveolae may be sites that regulate intracellular Ca2+ concentration and Ca2+ dependent signal transduction. This review will focus on the role of caveolae in controlling the spatial and temporal pattern of intracellular Ca2+ signaling.

PMID:
10643558
DOI:
10.1054/ceca.1999.0073
[Indexed for MEDLINE]

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