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Bone Marrow Transplant. 1999 Dec;24(11):1245-8.

Successful treatment of human herpesvirus-6 encephalitis after bone marrow transplantation.

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Department of Hematology/Oncology/Immunology and Rheumatology, University of Tübingen, Germany.


We report two cases of human herpesvirus-6 (HHV-6)-associated encephalitis in patients after BMT. Both patients reported distinct neurological symptoms with disorientation, sleepiness and loss of short-term memory. Diagnosis was based on PCR analysis of the cerebrospinal fluid (CSF) positive for HHV-6 variant B-DNA. After institution of therapy with foscarnet in both cases, neurological symptoms improved and in one patient clearance of HHV-6-DNA from CSF was demonstrated. These cases show that HHV-6 infection has to be considered in patients with neurological symptoms following BMT and effective treatment of HHV-6 encephalitis is possible if instituted early.

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