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Proc Natl Acad Sci U S A. 1976 May;73(5):1447-51.

Characterization of a gamma-carboxyglutamic acid-containing protein from bone.

Abstract

A gamma-carboxyglutamic acid-containing protein has been purified from the calcified tissues of several vertebrates. The presence of three-gamma-carboxyglutamic acid residues in the bovine protein was established by alkaline hydrolysis and amino acid analysis, a method based upon studies with synthetic gamma-carboxyglutamic acid. The identity of gamma-carboxyglutamic acid in the bovine protein was established by mass spectroscopy on the unknown amino acid isolated from alkaline hydrolysates.

PMID:
1064018
PMCID:
PMC430313
[Indexed for MEDLINE]
Free PMC Article
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