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Int J Mol Med. 2000 Feb;5(2):151-4.

Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review).

Author information

1
Kimmel Cancer Center, Thomas Jefferson University, 606 Bluemle Life Sciences Building, Philadelphia, PA 19107-5541, USA.

Abstract

The adapter protein Grb10 belongs to a superfamily of related proteins that include Grb7, Grb14 and the Caenorhabtidis elegans Mig10. The available data on Grb10 proteins suggest a role of these adapters in signaling downstream of several receptor tyrosine kinases. In the present review the focus is on the interaction between Grb10 proteins and the insulin-like growth factor receptor/insulin receptor, and the role of Grb10 in IGF-I/insulin-induced mitogenesis is discussed, considering that the data available are also partially discordant.

PMID:
10639593
DOI:
10.3892/ijmm.5.2.151
[Indexed for MEDLINE]

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