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Antimicrob Agents Chemother. 2000 Feb;44(2):453-5.

Characterization of TEM-56, a novel beta-lactamase produced by a Klebsiella pneumoniae clinical isolate.

Author information

1
Laboratoire de Bact¿eriologie, H¿opital Universitaire du Bocage, B.P. 1542, 21034 Dijon Cedex, France.

Abstract

TEM-56 produced by a Klebsiella pneumoniae clinical isolate is a novel beta-lactamase of isoelectric point 6.4 that confers a moderate resistance level to expanded-spectrum cephalosporins. The amino acid sequence deduced from the corresponding bla gene showed two amino acid replacements with respect to the TEM-2 sequence: Glu-104 to Lys and His-153 to Arg. This enzyme showed catalytic properties close to those of TEM-18. Thus, TEM-56 appears as a new TEM mutant, an intermediary between TEM-18 and the extended-spectrum beta-lactamase TEM-21.

PMID:
10639384
PMCID:
PMC89705
DOI:
10.1128/aac.44.2.453-455.2000
[Indexed for MEDLINE]
Free PMC Article

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