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Eur J Clin Pharmacol. 1999 Nov;55(9):639-43.

Arterial/venous plasma nicotine concentrations following nicotine nasal spray.

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1
Department of Pharmacology, University of Michigan, Ann Arbor 48109-0632, USA.

Abstract

BACKGROUND AND OBJECTIVES:

Arterial (A) and venous (V) plasma nicotine and cotinine concentrations were measured after nasal nicotine spray in tobacco smokers of both genders. The hypothesis for this research was that a greater A/V difference in plasma nicotine would be present in males than females because males have greater skeletal muscle mass to bind nicotine.

SUBJECTS AND METHODS:

Nine male and nine female healthy adult smokers were studied. They all abstained from use of tobacco overnight for 10 h or more prior to the study. Nicotine nasal spray was given in doses of 1-2.5 mg total, with half in each nostril while the subject was supine. Both A and V blood samples were obtained prior to and 3, 6, 10, 15, 20, and 30 min post-nasal nicotine spray.

RESULTS AND CONCLUSIONS:

Nasal nicotine administration produced greater A than V plasma levels. There were no gender differences in A/V nicotine concentrations, disproving the above hypothesis, suggesting that other physiochemical factors besides skeletal muscle mass must be involved. Heart rate increases correlated well with arterial plasma nicotine levels (r = 0.77). Males had less variance than females in the expected increase in arterial plasma nicotine concentrations with increased number of nasal sprays. Although there was considerable overlap, mean A cotinine concentrations were consistently slightly larger than V concentrations.

PMID:
10638392
DOI:
10.1007/s002280050686
[Indexed for MEDLINE]
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