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Trends Biochem Sci. 2000 Jan;25(1):24-8.

GHKL, an emergent ATPase/kinase superfamily.

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Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.


An interesting recent development is the recognition of a novel ATP-binding superfamily that includes diverse protein families such as DNA topoisomerase II, molecular chaperones Hsp90, DNA-mismatch-repair enzymes MutL and histidine kinases. The most singular unifying feature of this superfamily is the unconventional Bergerat ATP-binding fold. The far-reaching significance of this commonality is still in the process of being explored.

[Indexed for MEDLINE]

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