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Trends Biochem Sci. 2000 Jan;25(1):19-23.

Regulating actin-filament dynamics in vivo.

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  • 1Department of Biochemistry and Molecular Biology, and the Molecular, Cellular, and Integrative Neuroscience Program, Colorado State University, Fort Collins, CO 80523, USA.


The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover.

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