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J Neuroimmunol. 2000 Jan 24;102(2):163-71.

Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells.

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Department of Biology, University of North Carolina at Charlotte, 28223, USA.


Professional antigen presenting cells, such as macrophages, can be activated by intracellular calcium-dependent as well as calcium-independent mechanisms, depending upon the stimulus used. In this report, we addressed the mechanism of substance P-induced intracellular signalling in murine macrophages and dendritic cells. While no increases in intracellular calcium concentration were detected in macrophages or dendritic cells using sensitive fluorimetric techniques, substance P did induce rapid enhanced activation of NF-kappaB, a transcriptional activator known to regulate pro-inflammatory cytokines. These data provide an important mechanism by which substance P may augment the production of pro-inflammatory molecules.

[Indexed for MEDLINE]

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