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Bioorg Med Chem Lett. 2000 Jan 3;10(1):71-4.

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.

Author information

1
Department of Medicinal Chemistry, Janssen Research Foundation, Beerse, Belgium. lkennis@janbe.jnj.com

Abstract

The synthesis and biological activity of a series of benzofuro[3,2-c]pyridines and a benzothieno[3,2-c]pyridine are described. These compounds exhibit high affinity for the alpha 2-adrenoceptor, with high selectivity versus the alpha 1-receptor. Compound 1 also shows potent in vivo central activity and has been selected for further biological and clinical evaluation.

PMID:
10636247
DOI:
10.1016/s0960-894x(99)00591-0
[Indexed for MEDLINE]

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