Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2000 Jan 3;10(1):31-4.

The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family.

Author information

1
ChemBridge Corporation, San Diego, CA 92127, USA. twebb@chembridge.com

Abstract

Pharmacophore queries from previously known potent selective A3 antagonists were generated by Chem-X. These queries were used to search a pharmacophore database of diverse compounds (CNS-Set). In vitro assays of 186 'hits' yielded over 30 active compounds, for four adenosine receptor subtypes. This search strategy may also be applicable to the discovery of new ligands via receptor homology data.

PMID:
10636237
PMCID:
PMC5553072
DOI:
10.1016/s0960-894x(99)00583-1
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center