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Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8.

Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

Abstract

Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4.

PMID:
10636230
DOI:
10.1016/s0960-894x(99)00584-3
[Indexed for MEDLINE]

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