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Biophys Chem. 1999 Dec 13;82(2-3):157-63.

The adhesive binding site of cadherins revisited.

Author information

1
Brookdale Center for Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York University, NY 10029, USA.

Abstract

Cadherins are single-pass transmembrane proteins that, through their homophilic specificity, function in selective cell adhesion and sorting. They have a modular structure that includes an ectodomain composed of tandem 'cadherin domains,' which have a beta-sandwich topology similar to that of immunoglobulin domains. Some early experiments suggest that, for the 'classical' cadherins, the adhesive specificity is encoded in the membrane-distal amino-terminal cadherin domain. Here, we review these data, and present new data that supports this idea.

PMID:
10631798
DOI:
10.1016/s0301-4622(99)00115-5
[Indexed for MEDLINE]

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