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Curr Opin Immunol. 1999 Dec;11(6):657-62.

Rheumatoid arthritis and its animal models: the role of TNF-alpha and the possible absence of specific immune reactions.

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1
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.

Abstract

Rheumatoid arthritis is an organ-specific inflammatory disease of humans. Recent studies have focused on associations with non-MHC genes, new autoantigens and the role of innate immune responses. The success of anti-TNF-alpha in the majority (but, interestingly, not all) of patients has implications for disease mechanisms but the dangers of long-term therapy are becoming clearer. A number of new models of arthritis have been defined and emphasize the importance of the genetic make-up of the host. Attention has also focused on why the joint is a particularly vulnerable site for inflammatory responses.

PMID:
10631551
[Indexed for MEDLINE]
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