Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Immunol. 1999 Dec;11(6):657-62.

Rheumatoid arthritis and its animal models: the role of TNF-alpha and the possible absence of specific immune reactions.

Author information

Department of Medicine, Karolinska Hospital, Stockholm, Sweden.


Rheumatoid arthritis is an organ-specific inflammatory disease of humans. Recent studies have focused on associations with non-MHC genes, new autoantigens and the role of innate immune responses. The success of anti-TNF-alpha in the majority (but, interestingly, not all) of patients has implications for disease mechanisms but the dangers of long-term therapy are becoming clearer. A number of new models of arthritis have been defined and emphasize the importance of the genetic make-up of the host. Attention has also focused on why the joint is a particularly vulnerable site for inflammatory responses.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center