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Chem Biol. 1999 Dec;6(12):R319-25.

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases.

Author information

1
Department of Chemistry, Brown University, Providence, RI 02912-9108, USA. David_Cane@brown.edu

Abstract

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products.

PMID:
10631508
[Indexed for MEDLINE]
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