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Biochem Biophys Res Commun. 2000 Jan 19;267(2):603-8.

Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice.

Author information

1
Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, S-413 45, Sweden.

Erratum in

  • Biochem Biophys Res Commun. 2006 Sep 15;348(1):328. Bohlooly, YM [corrected to Bohlooly-Y, M].

Abstract

Growth hormone (GH) is important for skeletal growth as well as for a normal bone metabolism in adults. The skeletal growth and adult bone metabolism was studied in mice with an inactivated growth hormone receptor (GHR) gene. The lengths of femur, tibia, and crown-rump were, as expected, decreased in GHR-/- mice. Unexpectedly, GHR-/- mice displayed disproportional skeletal growth reflected by decreased femur/crown-rump and femur/tibia ratios. GHR-/- mice demonstrated decreased width of the growth plates in the long bones and disturbed ossification of the proximal tibial epiphysis. Furthermore, the area bone mineral density (BMD) as well as the bone mineral content (BMC)/body weight were markedly decreased in GHR-/- mice. The decrease in BMC in GHR-/- mice was not due to decreased trabecular volumetric BMD but to a decreased cross-sectional cortical bone area In conclusion, GHR-/- mice demonstrate disproportional skeletal growth and markedly decreased bone mineral content.

PMID:
10631109
DOI:
10.1006/bbrc.1999.1986
[Indexed for MEDLINE]

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