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Biochem Biophys Res Commun. 2000 Jan 19;267(2):593-6.

Interaction between GADD34 and kinesin superfamily, KIF3A.

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Department of Basic Gerontology, National Institute for Longevity Sciences, 36-3, Gengo Morioka-cho, Obu, Aichi, 474-8522, Japan.


GADD34 is one of a subset of proteins induced after DNA damage or cell growth arrest. To examine the function of GADD34, we used the yeast two-hybrid system to clone the protein that interacts with the murine GADD34. One cDNA clone was the C-terminal part of KIF3A gene including the tail domain. The interaction between GADD34 and KIF3A was confirmed in the NIH3T3 cells by in vivo two-hybrid analysis. We could detect that GADD34 was induced with methyl methanesulfonate; however, the mRNA induction of KIF3A was not detected.

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