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Arch Dis Child. 2000 Jan;82(1):71-5.

Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children.

Author information

1
Department of Clinical Biochemistry, St Bartholomew's and The Royal London, School of Medicine and Dentistry, Turner Street, London E1 2AD, UK. h.finney@mds.qmw.ac.uk

Abstract

AIM:

To establish a reference range in the paediatric population for the new glomerular filtration rate (GFR) marker, cystatin C, and to compare it with that of creatinine.

METHODS:

Cystatin C and creatinine were measured by particle enhanced nephelometric immunoassay (PENIA) and fixed interval Jaff┬┐e methods, respectively, in 291 children aged 1 day to 17 years, including 30 premature infants with gestational ages ranging from 24 to 36 weeks.

RESULTS:

In the premature infants, concentrations of both cystatin C and creatinine were significantly raised compared with term infants, with cystatin C concentrations being between 1.10 and 2.06 mg/litre and creatinine between 32 and 135 micromol/litre. In premature infants, there was no significant relation between gestational age and cystatin C or creatinine concentration. Creatinine concentrations fell to a nadir at 4 months of age, rising gradually to adult values by about 15-17 years of age, in contrast to cystatin C, which fell to a mean concentration of 0.80 mg/litre by the 1st year of life, and remained constant throughout adulthood up to the age of 50 years. Neither analyte showed any influence of sex.

CONCLUSION:

The measurement of cystatin C, rather than creatinine, is more practical for monitoring GFR changes in the paediatric population.

PMID:
10630919
PMCID:
PMC1718178
[Indexed for MEDLINE]
Free PMC Article

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