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J Antimicrob Chemother. 2000 Jan;45(1):9-13.

Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.

Author information

1
Institute for Medical Microbiology and Immunology, Panum Inst. 24.1, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark. O.Ciofu@immi.ku.dk

Abstract

Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

PMID:
10629007
DOI:
10.1093/jac/45.1.9
[Indexed for MEDLINE]

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