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Anticancer Res. 1999 Sep-Oct;19(5B):4305-9.

Immunohistochemical study on tumor angiogenic factors in non-small cell lung cancer.

Author information

1
Department of Thoracic Surgery, Tohoku University, Sendai, Japan.

Abstract

BACKGROUND:

In order to elucidate the roles of tumor angiogenesis in lung carcinogenesis, the expressions of several angiogenic factors in lung carcinoma tissues were examined.

MATERIALS AND METHODS:

Tissue specimens from 112 cases of resected non-small cell lung cancer (NSCLC) were studied. The expressions of platelet-derived endothelial cell growth factor (PD-ECGF) and vascular endothelial growth factor (VEGF) were examined immunohistochemically. Microvessel density (MVD) was also evaluated.

RESULTS:

VEGF-positive cases were observed more frequently in advanced stage lung cancers than in early cancers, and VEGF-positive tumors had higher MVD than VEGF-negative tumors, while such differences were not observed for PD-ECGF. In squamous cell carcinoma, the patients with high-MVD tumor had significantly worse survival than those with low-MVD tumor.

CONCLUSIONS:

Our results suggest that VEGF plays an important role in angiogenesis of lung cancers, while the contribution of PD-ECGF may be limited.

PMID:
10628391
[Indexed for MEDLINE]

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