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Blood. 2000 Jan 15;95(2):719-20.

Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system.

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Departments of Biochemistry and Human Genetics, University of Würzburg, Würzburg, Germany. reuter@biozentrum.uni-wuerzburg


Three of at least 8 Fanconi anemia (FA) genes have been cloned (FANCA, FANCC, FANCG), but their functions remain unknown. Using the yeast 2-hybrid system and full-length cDNA, the authors found a strong interaction between FANCA and FANCG proteins. They also obtained evidence for a weak interaction between FANCA and FANCC. Neither FANCA nor FANCC was found to interact with itself. These results support the notion of a functional association between the FA gene products. (Blood. 2000;95:719-720).

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