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Immunity. 1999 Dec;11(6):753-61.

Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo.

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1
Department of Pathology, Weill Medical College of Cornell University, New York, USA. gjrandol@mail.med.cornell.edu

Abstract

We investigated the differentiation and trafficking of inflammatory monocytes that phagocytosed subcutaneously injected fluorescent microspheres. As expected, most of the monocytes became microsphere+ macrophages, which remained in subcutaneous tissue. However, about 25% of latex+ cells migrated to the T cell area of draining lymph nodes, where they expressed dendritic cell (DC)-restricted markers and high levels of costimulatory molecules. Microsphere-transporting cells were distinct from resident skin DCs, and this transport was reduced by more than 85% in monocyte-deficient osteopetrotic mice. Thus, a substantial minority of inflammatory monocytes carry phagocytosed particles to lymph nodes and differentiate into DCs.

PMID:
10626897
[Indexed for MEDLINE]
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