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Immunity. 1999 Dec;11(6):689-98.

Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions.

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1
Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To ascertain the essential functions of Ox40L, we generated and characterized Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity response, a dendritic cell-dependent T cell-mediated response, due to defects in T cell priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T cell homing or humoral immune responses. In vitro, Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo for dendritic cell:T cell interactions.

PMID:
10626891
[Indexed for MEDLINE]
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