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J Hepatol. 1999;31 Suppl 1:119-23.

Hepatitis C and HIV infection: biological, clinical, and therapeutic implications.

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1
Service of Infectious Diseases, Hospital Carlos III, Instituto de Salud Carlos III Madrid, Spain. vsoriano@dragonet.es

Abstract

As deaths from AIDS continue to decline in HIV-infected persons, liver disease is becoming an increasing cause of hospital admission and death in HIV-HCV co-infected persons. The problem is particularly relevant among intravenous drug users and haemophiliacs, most of whom are co-infected. Moreover, the risk of hepatotoxicity is higher with anti-HIV drugs among patients with chronic hepatitis C. Treatment with alpha-interferon provides a similar rate of response in non-severely immunosuppressed HIV-positive subjects as in HIV-negatives, and preliminary results from trials using the combination of interferon plus ribavirin in HIV-HCV co-infection look very promising for both rates of sustained response and safety.

PMID:
10622573
[Indexed for MEDLINE]
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