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Genes Cells. 1999 Dec;4(12):685-96.

Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.

Author information

1
Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. yito@virus.kyoto-u.ac.jp

Abstract

The Runt domain transcription factor PEBP2/CBF is a heterodimer of alpha and beta subunits. Of the three mammalian alpha subunit genes, which are homologues of the Drosophila gene runt, PEBP2alphaA/CBFA1 and PEBP2alphaB/AML1 are critical regulators of osteogenesis and haematopoiesis, respectively. A unique functional interaction between PEBP2alphaB/AML1 and Ets-1 was recently observed, and provides a clear example of context-dependent transcriptional regulation. An elaborate mechanism of cooperation between the two factors may represent a basis for tissue-specific gene expression, which is thought to be achieved by combinations of specific sets of transcription factors unique to each cell lineage or stage of differentiation. A possible molecular basis for the critical role(s) played by PEBP2/CBF in tissue determination is discussed in light of these observations.

PMID:
10620014
[Indexed for MEDLINE]
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