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J Neurotrauma. 1999 Dec;16(12):1235-9.

Treatment of a recurrent subdural hematoma using urokinase.

Author information

1
Department of Neurosurgery, Mount Sinai Medical Center, New York, New York, USA. arginteanu@yahoo.com

Abstract

Previous reports describe the intraventricular, subarachnoid, and intraparenchymal use of thrombolytic agents. However, the use of thrombolytic agents in the management of extraaxial hematomas has not been described. Following the evacuation of a subacute subdural hematoma, this 48-year-old woman experienced declining neurologic function due to the reaccumulation of blood in the subdural space. Urokinase was administered via a subdural drain. The patient experienced rapid clinical improvement and radiographic resolution of the recrudescent subdural hematoma. If repeat surgical evacuation of a subdural hematoma is not possible, urokinase may be instilled into the subdural space to enhance drainage of a subdural hematoma.

PMID:
10619201
DOI:
10.1089/neu.1999.16.1235
[Indexed for MEDLINE]

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