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Mol Cell. 1999 Nov;4(5):735-43.

A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes.

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1
Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Federal Republic of Germany.

Abstract

The activation of many genes requires the concerted effort of two or more transcription factors. Although C/EBP beta is known to cooperate with Myb to induce transcription of the granulocyte-specific mim-1 gene, the molecular mechanism of this cooperativity is undefined. We show that the N terminus of the full-length C/EBP beta isoform, which is essential for induction of the mim-1 gene in chromatin, interacts specifically with the SWI/SNF complex. Grafting this domain onto Myb generates a chimeric activator that recruits SWI/SNF and induces mim-1 transcription in the absence of C/EBP beta. Interaction between C/EBP beta and SWI/SNF is essential for activating a subgroup of resident target genes in chromatin and may represent a major determinant of combinatorial gene regulation in eukaryotes.

PMID:
10619021
DOI:
10.1016/s1097-2765(00)80384-6
[Indexed for MEDLINE]
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