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Clin Diagn Lab Immunol. 2000 Jan;7(1):125-8.

Development of positive selectable markers for the fungal pathogen Cryptococcus neoformans.

Author information

1
Edward A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri 63104, USA.

Abstract

Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningitis in approximately 10% of patients with AIDS. New selectable markers which confer resistance to G418 or phleomycin when transformed into C. neoformans were made. A hygromycin-selectable marker was modified to allow selection with a single copy of the marker.

PMID:
10618292
PMCID:
PMC95837
DOI:
10.1128/cdli.7.1.125-128.2000
[Indexed for MEDLINE]
Free PMC Article

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