Send to

Choose Destination
Bioorg Med Chem Lett. 1999 Dec 20;9(24):3447-52.

Novel synthetic analogs of the Pseudomonas autoinducer.

Author information

PathoGenesis Corporation, Seattle, WA 98119, USA.


Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa. Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ reporter construct.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center