Format

Send to

Choose Destination
Bioorg Med Chem Lett. 1999 Dec 20;9(24):3435-8.

Delta opioid binding selectivity of 3-ether analogs of naltrindole.

Author information

1
Laboratory of Medicinal Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892, USA.

Abstract

Masking of the 3-phenol of naltrindole as a range of ethers caused a decrease in binding affinity at all three opiate receptors (mu, kappa, delta), however for the methyl ether, the reduction in affinity at both mu and kappa was greater than at delta, thereby increasing delta binding selectivity.

PMID:
10617086
DOI:
10.1016/s0960-894x(99)00622-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center