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Prog Drug Res. 1999;53:1-51.

U-50,488 and the kappa receptor. Part II: 1991-1998.

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Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556-5670, USA.


This review, Part II, follows an earlier article, Part I, published in volume 52 of this series. Part II is a discussion of centrally and peripherally acting kappa agonists which can be considered analogs of U-50,488. Included also are three classes of kappa agonists which fall outside of the scope of the general structure of U-50,488. These are benzodiazepines, phenothiazines and diazobicyclonanones. The discussion also covers other pertinent topics including labelled ligands and sigma receptor.

[Indexed for MEDLINE]

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